Turkish Archives of Pediatrics
Original Article

Evaluation of Hepatosteatosis-Induced Increase in Fibrosity by Two-Dimensional Shear Wave Elastography in Children with Obesity and Comparison with Healthy Peers

1.

Department of Radiology, Kartal Dr. Lütfi Kırdar City Hospital, İstanbul, Turkey

2.

Department of Pediatric Endocrinology, Üsküdar University Faculty of Medicine, İstanbul, Turkey

Turk Arch Pediatr 2024; 59: 205-213
DOI: 10.5152/TurkArchPediatr.2024.23237
Read: 277 Downloads: 115 Published: 01 March 2024

 

Objective: The increase in the prevalence of obesity, nonalcoholic fatty liver disease (NAFLD), and related comorbidities in children creates a social and financial burden. In our study, we aimed to evaluate liver findings together with anthropometric and laboratory data with twodimensional shear wave elastography (2D-SWE), one of the SWE types, which is a noninvasive method for assessing tissue stiffness in children with obesity, and to obtain quantitative data that can be used in early diagnosis and follow-up.

Materials and Methods: In our single-center, observational cross-sectional study, liver gray scale findings, 2D-SWE findings, anthropometric measurements, and laboratory values of 48 children with obesity and 50 healthy children aged between 5 and 18 years, both between groups and in prepubertal and pubertal subgroups, are compared.

Results: A significant difference was found in the liver stiffness indicator kilopascal (kPA) values and between aspartate aminotransferase values in the prepubertal period and alanine aminotransferase values in the pubertal period (P < .001). No significant difference was found between insulin, HOMA-IR, waist circumference, waist/height ratio, and kPA.

Conclusion: Two-dimensional shear wave elastography can be easily applied in the pediatric population as a practical, noninvasive, reproducible, and highly compatible technique. In this regard, 2D-SWE may be useful in the early diagnosis and follow-up of hepatosteatosis and fibrosis in children with obesity and NAFLD-risky cases.

Cite this article as: Düzkalır HG, Söbü E, Aydıner Ö. Evaluation of hepatosteatosis-induced increase in fibrosity by two-dimensional shear wave elastography in children with obesity and comparison with healthy peers. Turk Arch Pediatr. 2024;59(2):205-213.

Files
EISSN 2757-6256