Turkish Archives of Pediatrics
Original Article

Single-Center Experience in Vaccination of Children in Special Risk Groups: A Multidisciplinary Institutional Consensus Protocol


Division of Pediatrics, Department of Social Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey


Institute of Health Sciences, Marmara University, İstanbul, Turkey


Department of Pediatric Infectious Diseases, Marmara University Faculty of Medicine, İstanbul, Turkey


Department of Pediatrics, Marmara University Faculty of Medicine, İstanbul, Turkey


Department of Pediatric Hematology and Oncology, Marmara University Faculty of Medicine, İstanbul, Turkey


Department of Pediatric Allergy and Immunology, Marmara University Faculty of Medicine, İstanbul, Turkey

Turk Arch Pediatr 2023; 58: 531-538
DOI: 10.5152/TurkArchPediatr.2023.23097
Read: 798 Downloads: 330 Published: 25 August 2023

Objective: Despite marked improvements in the accessibility of childhood vaccines, knowledge gaps remain about the vaccination of children in special risk groups (SRG). This study aimed to analyze the clinical data of children vaccinated in SRG in a single-center unit to contribute to the clinical evidence for the specific planning of immunization of children in SRG. The second- ary aim is to present institutional consensus on the vaccination of children in SRG.

Materials and Methods: This retrospective study was conducted at a single-center pediatric vaccination clinic. Patient charts between 2018 and 2021 were retrospectively reviewed, and clinical and laboratory data were extracted. Serial joint meetings with multiple healthcare pro- fessionals were performed to develop an institutional protocol for vaccination.

Results: There were 479 children vaccinated between 2018 and 2021 for reasons such as post- chemotherapy, after hematopoietic stem cell transplantation, before/after solid organ trans- plantation, allergies, and chronic diseases. Of these, 298 (62.2%) children vaccinated in the unit due to a history of food or vaccine allergies were excluded. One hundred eighty-one children were vaccinated at a median age of 11 [7-15] years. Most children were vaccinated after treat- ment for malignancies. Solid tumors were the most frequent malignancy (67%), followed by acute lymphoblastic leukemia (29.0%) and acute myeloid leukemia (4.0%). Institutional vacci- nation protocols for cancer survivors, hematopoietic stem cells, and solid organ recipient chil- dren were developed and presented.

Conclusion: There is a need to prepare national guidelines for vaccinating children with altered immunocompetence. Sharing vaccination practices by multidisciplinary vaccination units might increase and provide knowledge to develop national policies.

Cite this article as: Barış HE, Kepenekli E, Akbolat Sakar Fİ, et al. Single-center experience in vaccination of children in special risk groups: A multidisciplinary institutional consensus protocol. Turk Arch Pediatr. 2023;58(5):531-538.

EISSN 2757-6256