Turkish Archives of Pediatrics
Original Article

Role of Serum Apelin in the Diagnosis of Early-Onset Neonatal Sepsis


Department of Pediatrics, Al Azhar University Faculty of Medicine for Girls, Cairo, Egypt


Department of Clinical Pathology, Al Azhar University Faculty of Medicine for Girls, Cairo, Egypt

Turk Arch Pediatr 2021; 56: 563-568
DOI: 10.5152/TurkArchPediatr.2021.21108
Read: 157 Downloads: 65 Published: 01 November 2021

Objective: Apelin is a proinflammatory adipocyte-derived factor. The aim of this study was to evaluate the role and significance of serum apelin as a new sepsis marker in the identification of full-term and preterm new-born infants with early-onset sepsis.

Material and Methods: This was a case-control study. We included 80 neonates. The cases were divided into 2 groups; neonates with early-onset sepsis and control group with neonates non-sepsis. Apelin was quantified by enzyme-linked immunosorbent assay.

Results: There was a significant elevation in the mean values of serum apelin in the early-onset sepsis group (1214.7 ± 273.06 pg/mmol) than in the non-septic neonates 116.27 ± 21.96 pg/mmol (P < .0001). Apelin values were correlated to clinical sepsis and hematological scores as well as C-reactive protein. Serum apelin concentration was significantly higher among culturepositive cases than the culture-negative cases (mean ± SD was 1239.52 ± 268.47 and 929.42 ± 136.97 pg/mmol, respectively, P < .0001). Moreover, the apelin level was higher in non-survivor neonates than in the survivors in the early-onset sepsis group. No significant difference was found between preterm and full-term new-born infants with regard to the apelin values. The best cut-off estimate of apelin to diagnose early sepsis was >178.33 pg/mmol.

Conclusion: Apelin may be useful in the diagnosis and prognostic prediction of neonates with early-onset sepsis.

Cite this article as: ELMeneza SAEN, Mohamed Said El Bagoury IMS, El Sayed Mohamed K. Role of serum apelin in the diagnosis of early-onset neonatal sepsis. Turk Arch Pediatr. 2021; 56(6): 563-568.

EISSN 2757-6256